We are pleased to present this month’s interesting study, “A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus” authored by:

Amrita K Singh, Garrett Allington, Stephen Viviano, Stephen McGee, Emre Kiziltug, Shaojie Ma, Shujuan Zhao, Kedous Y Mekbib, John P Shohfi, Phan Q Duy, Tyrone DeSpenza Jr, Charuta G Furey, Benjamin C Reeves, Hannah Smith, Andre M M Sousa, Adriana Cherskov, August Alloco, Carol Nelson-Williams, Shozeb Haider, Syed R A Rizvi, Seth L Alper, Nenad Sestan, Hermela Shimelis, Lauren K Walsh, Richard P Lifton, Andres Moreno-De-Luca, Sheng Chih Jin, Paul Kruszka, Engin Deniz and Kristopher T Kahle

This study from Harvard and Yale Universities suggests that SMARCC1 variants lead to congenital hydrocephalus by altering the epigenetic regulation of gene expression of neural progenitor cell proliferation. These findings have the potential to improve the prognosis and treatment of affected children.

Read the Full Paper here: https://pubmed.ncbi.nlm.nih.gov/38128548/

We are pleased to present this month’s interesting study, “Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography”, authored by Pragalv Karki, Matthew C Murphy, Petrice M Cogswell, Matthew L Senjem, Jonathan Graff-Radford, Benjamin D Elder, Avital Perry, Christopher S Graffeo, Fredic B Meyer, Clifford R Jack Jr, Richard L Ehman and John Huston 3rd.

This study uses MR Elastography to predict surgical outcomes in Normal Pressure Hydrocephalus (NPH), offering a non invasive alternative to traditional methods. Results suggest improved NPH diagnostic odds ratio and positive predictive value. This advancement could significantly improve the management of Normal Pressure Hydrocephalus, impacting the lives of those affected by this condition.

Read the Full Paper here: https://pubmed.ncbi.nlm.nih.gov/38272572/

“Ventriculoatrial Shunt Versus Ventriculoperitoneal Shunt: A Systematic Review and Meta-Analysis” authored by: Leonardo de Barros Oliveira, Fernando Hakim, Gabriel da Silva Semione, Raphael Bertani, Savio Batista, Lucca B Palavani, Marcelo Porto Sousa, Diego F Gomez-Amarillo, Isabella Mejia-Michelsen, Fernando Campos Gomes Pinto, Nicollas Nunes Rabelo, Leonardo C Welling, Eberval Gadelha Figueiredo.

Exciting findings from the latest research by the Hydrocephalus Society! A recent study compared ventriculoatrial and ventriculoperitoneal shunting techniques, revealing no significant differences in outcomes. More research, especially in adults, is needed. Emphasizing the importance of future randomized trials for optimal cerebrospinal fluid drainage. This work supports personalized neurosurgical approaches, improving decision-making in hydrocephalus treatment. Advancing strategies for managing hydrocephalus.

#HydrocephalusResearch #Neurosurgery #MedicalAdvancements 🧠✨

Read the Full Paper here: https://pubmed.ncbi.nlm.nih.gov/38117090/

“The glymphatic system for neurosurgeons: a scoping review ” authored by:

Mohammad Al Masri, Alba Corell, Isak Michaëlsson, Asgeir S. Jakola and Thomas Skoglund.

This review by the Neurosurgery department at Gothenburg, offers an insightful analysis on the impact of glymphatic system in different conditions such as Idiopathic normal pressure hydrocephalus, Idiopathic intracranial hypertension, Subarachnoid hemorrhage, Stroke, Intracranial tumors and Traumatic brain injury and its potential role as a therapeutic target.

doi: 10.1007/s10143-024-02291-6

Read more here: https://link.springer.com/article/10.1007/s10143-024-02291-6

“Prevalence of Possible Idiopathic Normal Pressure Hydrocephalus in Sweden: A Population-Based MRI Study in 791 70-year-old Participants” authored by: Clara Constantinescu, MD, Carsten Wikkelsø, MD, PhD, Eric Westman, PhD, Doerthe Ziegelitz, MD, PhD, Daniel Jaraj, MD, PhD ,Lina Rydén, MD, PhD, Ingmar Skoog, MD, PhD and Mats Tullberg, MD, PhD.

This paper by University of Gothenburg highlights the epidemiological impact of iNPH in the aging society and shows that iNPH is probably a largely underdiagnosed and undertreated disorder.

Read more here: https://www.neurology.org/doi/10.1212/WNL.0000000000208037

Dear Colleagues and Friends,

Hydrocephalus Society is delighted to invite you to register for yet another session of the Global Webinar Series 2023-2024: Adult CSF dynamics disturbances: Basics and Management.

Join us now for FREE and reserve your spot for Part 4!

Dear colleagues and friends,

An exciting year is about to come to an end. We are still facing challenging times including military conflicts, economic disparities and burdens, and effects of climate change. Many patients in the world lack adequate or timely medical care. We hope reason will prevail and we are hoping for a better and more peaceful 2024.

This time of year holds a special place in our hearts, as it reminds us of the values that define us as a community – friendship, compassion, and the joy of giving.

On behalf of the Hydrocephalus Society, I wish you a Merry Christmas and a New Year filled with hope, compassion, and solidarity as well as with many exciting opportunities within our field.

Sincerely yours,

Mats Tullberg

President of the Hydrocephalus Society

Dear Colleagues & Friends,
The Board and the Office team of the Hydrocephalus Society would like to wish you a very Happy Easter with lots of health and happiness for you and your families.

Hydrocephalus Society is delighted to invite you to register for yet another session of the Global Webinar Series 2022-2023: Cerebrospinal fluid Dynamic Disturbances in Adults – Part 5: Hakim’s Disease: Complications

Register FOR FREE to reserve your spot!